Growth Factors and Aging Skin: Reinforcing the Skin’s Natural Renewal

Across every decade, skin keeps doing what it has always done: renewing, adapting, maintaining itself. The question is never whether it can do those things, but how well it is supported in doing them. Growth Factors are proteins the skin produces on its own, and their role in that process is specific: they carry the signals that coordinate renewal, sustain firmness, and keep the activity running that skin depends on to look and perform at its best.

Topical Growth Factors, at a clinically meaningful concentration, support skin with more of what it already produces naturally. Applied consistently, they reinforce the processes already underway rather than overriding them, which is what makes a formula built around them perform differently from one that addresses only the surface.

Growth Factors carry signals from cell to cell, encouraging renewal, supporting firmness and density, and keeping the processes active that give skin its resilience and consistency. With sufficient levels of those signals present, skin performs well: texture stays even, the surface looks healthy, and the face maintains its definition across the years.

Formulation determines whether this translates into practice or stays in principle. A 3% Growth Factor Complex is calibrated to operate at a clinically meaningful level, where results can be measured rather than simply perceived. The gap between “felt different” and “measured differently” is precisely where clinical testing does its work.

Peptides contribute to the same goal from a distinct angle. Growth Factors coordinate broader activity; Peptides encourage support for firmness and skin density. At 3% and 9% respectively, the two together address considerably more than either ingredient reaches alone.

The Multi Peptides & GF Advanced Lifting Serum has become one of the brand's most reordered serums, a status earned through results. Years of formulation work went into stabilizing a 3% sh-Oligopeptide-1 (Growth Factor) Complex at a concentration high enough to register on skin. It is paired with a 9% Lifting Peptide Complex, built to reach the same expression lines from a different angle. Growth Factors act as messengers, supporting renewal and firmness, and this concentration gives more material than skin typically produces on its own.

MSM (Methylsulfonylmethane) works as an antioxidant that reinforces skin's strength and elasticity, while Copper Lysinate stabilizes the surrounding skin environment and supports visibly firmer contours. Phospholipids and Glycolipids let the formula integrate into skin rather than sit on top of it, closer to a second skin layer than a treatment step. Silky, lightweight, and non-sticky, it absorbs quickly without pilling under SPF or makeup, and layers cleanly alongside other serums in a multi-step routine. Fragrance-free, non-comedogenic, dermatologically tested for sensitive skin, and ophthalmologically tested for the eye area, the serum is built for skin at any stage, not just one decade or concern.

The Multi Peptides & GF Advanced Lifting Serum is formulated for all skin types, fragrance-free and non-comedogenic, with dermatological and ophthalmological testing that confirms suitability for sensitive skin and the eye area alike. Designed for skin at any age and stage, the serum is not built around a single concern or a specific decade; its scope is broader than that.

The formula has also been tested specifically on skin that has changed following significant weight loss, a concern rarely addressed in clinical skincare programs. In a panel of 18 participants, 100% saw tighter, firmer-looking skin, and 100% observed visible re-plumping after consistent use.

Testing tracked results at several points over 8 weeks. 

• On first use, 100% of participants experienced an immediate increase in skin hydration, with +21% more hydrated skin measured at 15 minutes.* 
• At 4 weeks, 87% saw an overall reduction in fine lines, including a 25% reduction in forehead line length, with skin appearing smoother and more radiant.* 
• At 8 weeks, 86% reported visibly lifted, less saggy skin.** 
• Also at 8 weeks, instrumental analysis measured a 20% average reduction in fine lines across the 9 most common expression line types, and a 97% reduction in eye area wrinkles, including a 24% reduction in crow's feet.*** 
• In a separate panel studied for skin sagging following weight loss, 100% reported tighter, firmer-looking skin after consistent use.**** 

*Clinical testing via instrumental analysis, 37 participants, twice-daily use for 4 weeks. 

**Result based on self-assessment, 35 participants, twice-daily use. 

***Clinical testing via instrumental analysis, 38 participants, twice-daily use for 8 weeks. 

****Self-assessment, 18 participants following weight loss, twice-daily use. 

Serum order follows consistency, not category: the lightest, water-based formulas go on first, and heavier, oil-based or creamy textures follow after. Exfoliating serums are the one exception, applied before anything else regardless of how thin or thick they are, since they prepare the skin's surface to accept the actives that come next. Once that step is done, the Multi Peptides & GF Advanced Lifting Serum falls early in the sequence, applied directly after the 35% Vitamin C+ Perfecting Serum and ahead of thicker brightening and hydrating formulas. Placed there, it reaches skin that has already been exfoliated and briefly treated with vitamin C, but before heavier textures have a chance to sit on the surface and slow absorption.

For a complete firming routine, the natural pairing is the Peptides & Antioxidants Advanced Firming Daily Treatment, which works at the surface while the Multi Peptides & GF Advanced Lifting Serum works on a deeper level. On its own, the GF Serum has shown 86% of users seeing lifted skin with reduced sagging, and the Daily Treatment is formulated to visibly firm and refine skin within a month of consistent use. Together, the two form the Ultimate Lifting Duo, a set designed specifically around this combination. Apply 1 to 3 pumps of the GF Serum after cleansing, allow absorption, then follow with the Daily Treatment and any finishing products.

Explore the Ultimate Lifting Duo